Inter-α-trypsin Inhibitor

SHAPs, the Heavy Chains of Inter- - Trypsin Inhibitor

Rapid Communication : The Porcine Inter - α Trypsin Inhibitor - Heavy Chain 4 ( ITIH 4 ) Gene Maps to Chromosome 131

1The authors thank A. L. Archibald, M. F. Rothschild, and the EC PiGMaP group for distribution of DNA from the PiGMaP reference families, and D. Nicholson, C. Haley, and G. J. Lee for provision of database services and linkage analyses. Published as paper no. 11935, Journal Series, Agric. Res. Div., Univ. of Nebraska, Lincoln 68583-0908. 2To whom correspondence should be addressed: phone: (402)...

Calorimetry of some trypsin-trypsin inhibitor reactions.

The heats of reaction of trypsin with soybean (Kunitz), ovomucoid, and lima bean inhibitors have been measured at pH 5.0 and 10’ and 25”. All the reactions were endothermic, with AH ranging from 8.6 Cal per mole for the lima bean inhibitor to 15.3 Cal per mole for the soybean inhibitor. Equilibrium constants for the association were calculated from the dependence of residual tryptic activity up...

Inter-α-inhibitor Impairs TSG-6-induced Hyaluronan Cross-linking*

Under inflammatory conditions and in the matrix of the cumulus-oocyte complex, the polysaccharide hyaluronan (HA) becomes decorated covalently with heavy chains (HCs) of the serum glycoprotein inter-α-inhibitor (IαI). This alters the functional properties of the HA as well as its structural role within extracellular matrices. The covalent transfer of HCs from IαI to HA is catalyzed by TSG-6 (tu...

Isolation from Beef Pancreas of Crystalline Trypsinogen, Trypsin, a Trypsin Inhibitor, and an Inhibitor-trypsin Compound

Methods are described for the isolation and crystallization of trypsinogen, trypsin, a substance which inhibits trypsin, and an inhibitor-trypsin compound. Analyses and some of the properties of these compounds are given.